Coronavirus COVID-19 (SARS-CoV-2) Research Products

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As the number of cases of COVID-19 continues to spread around the world, many countries have decided to start clinical trials to find a cure for this virus. Several molecules, all well-known and approved to treat other pathologies like HIV or Malaria, are currently being tested across the globe. From research to quality control standards, TRC has developed a series of products to support the scientific community in the development and controls of candidate vaccines and therapeutics against the SARS-COV-2.

Discover our complete range of inhibitors and modulators along with building blocks, metabolites, impurities, and labeled isotopes of various drugs.

Virus-Host Fusion Inhibitors

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Fusion Inhibitors, also known as entry inhibitors, are a class of antiretroviral (ARV) drugs. This class of antiviral drugs is used primarily in the treatment of HIV. As the name implies these inhibitors prevent viruses from entering or “fusing” with the host cells. Fusion inhibitors bind to envelope proteins on the exterior of the virus, effectively preventing the structural changes necessary to infuse with the host cell. Without the ability to enter the host cells the virus no longer have access to the machinery required to replicate and grow.

Discover our complete range of inhibitors and modulators along with building blocks, metabolites, impurities, and labeled isotopes.

Protease Inhibitors

Protease Inhibitors are a class of antivirals drugs used to treat a variety of viral infections, in particular HIV and HCV. These groups of inhibitors act by selectively binding to viral proteases during viral replication. In turn, preventing the proteolytic cleavage of protein precursors necessary to produce infectious viral particles. As a result, these newly replicated viruses are defective and unable to replicate and infect more host cells.

Discover our complete range of inhibitors and modulators along with building blocks, metabolites, impurities, and labeled isotopes.

RdRp Inhibitors

RNA-dependent RNA polymerase Inhibitors or RdRp inhibitors for short are a class of antiviral drugs. These inhibitors act to block the function of viral enzyme RNA-dependent RNA polymerase. RdRp is an essential enzyme used by viruses to replicate their genetic material and initiate viral replication. Once the enzyme is inhibited, viral replication is stopped, and the virus can no longer grow and infect more host cells.

Discover our complete range of inhibitors and modulators along with building blocks, metabolites, impurities, and labeled isotopes.

Bromodomain Inhibitors

Bromodomain Inhibitors are a class of antiviral drugs commonly used in the treatment of HIV. These molecules bind to regions of proteins known as bromodomains— which bind acetylated lysines in histone tails. Proteins that contain bromodomains are also epigenetic regulators, which play an important role in gene expression and regulation. This class of inhibitors blocks these protein interactions and in turn, prevents viral replication within the host cell.

Discover our complete range of inhibitors and modulators along with building blocks, metabolites, impurities, and labeled isotopes.

Antivirals

Antiviral drugs are a class of medication used specifically for treating viral infections. Most antivirals are used for specific viral infections, while some are effective against a wide spectrum of viruses. Antiviral medications are not designed to destroy their target pathogen but instead inhibit a particular phase of viral replication. This could include stages, such as the attachment to a host cell, replication of viral components, or the release of infectious viral particles.

Discover our complete range of inhibitors and modulators along with building blocks, metabolites, impurities, and labeled isotopes.

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